The challenge in all settings is to make the difficult decisions in a way that is defensible, justifiable, ethical, and equitableSo write Nick Freemantle and Suzanne Hill in their introduction to this important discussion on decision making in the reimbursement of pharmaceuticals. Based around a programme supported by the World Health Organization, chapters by leading academics involved in the research tackle such major issues as international pharmaceutical policy, tensions in licensing policies, priority setting, and relationships between the stakeholders.Chapters includeDevelopment of marketing authorisation procedures for pharmaceuticalsInterpreting clinical evidenceInternational pharmaceutical policy: health creation or wealth creation?Development of fourth hurdle policies around the worldEconomic modelling in drug reimbursementPriority setting in health care: matching decision criteria with policy objectivesTensions in licensing and reimbursement decisions: case of riluzole for amytrophic lateral sclerosisRelationship between stakeholders: managing the war of wordsMedicine and the media: good information or misleading hype?How to promote quality use of cost-effective medicines Using economic evaluation to inform health policy and reimbursement: making it happen and making it sustainablePricing of pharmaceuticalsEvaluating pharmaceuticals for health policy in low and middle income country settings.Besides the controversial issues there is a wealth of practical information including economic modelling and the experiences from the WHO programme, providing readers with workable examples. This is essential reading for clinical researchers in pharmaceuticals and policy makers everywhere.

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