Focusing on basic experimental diabetes research, this text is a useful resource for graduate students, research fellows, basic academic and pharmacological researchers, and clinical investigators. Fifty-one international specialists discuss the mechanisms of insular resistance, as discerned from a variety of animal models. Nineteen chapters explore metabolism and hypertension, molecular and genetic aspects, and aging. A sampling of topics include: the roles of insulin resistance and glycogen synthesis in liver, muscle and adipose tissue; molecular features of insulin resistance, obesity and type 2 diabetes in non-human primates; and the effect of age on the emergence of insulin resistance.

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