This volume presents a critical appraisal of the neurological literature on neuromuscular disease from an evidence-based perspective. Writing in a readable, accessible style, the author considers, in detail, a broad range of the published literature relevant not only to questions of treatment, but also to issues of diagnosis and prognosis. Through a series of questions and answers concerning specific neuromuscular disorders, each chapter critiques the best available evidence to illustrate strengths and weaknesses of the data and make the reader aware of the quality of clinical research studies in general. Introductory chapters facilitate this learning process by elucidating the epidemiological and biostatistical issues pertinent to diagnosis, treatment, and prognosis. A broad range of disorders of the anterior horn cell, nerve roots, peripheral nerves, neuromuscular junction, and muscle are critically appraised and discussed.