In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessmentand prediction of ADMET properties. Although the previous chapterlayout has been retained, substantial revisions have been made, with newtopics such as pro-drugs, active metabolites and transporters covered indetail in a manner useful to the Drug Discovery scientist. The authorsdiscuss the parameters and processes important for the absorption, distributionand retention of drug compounds in the body, plus the potentialproblems created by their transformation into toxic byproducts. Uniquely comprehensive, the book relates physicochemistry and chemical structureto pharmacokinetic properties and ultimately drug efficacy and safety.While aimed at all those dealing professionally with the developmentand application of pharmaceutical substances, the readily comprehensiblestyle makes this book equally suitable for students of pharmacy andrelated subjects.

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